![]() I, Corresponding circadian distribution and resultant vector showing a preferred time for seizure occurrence around 18:00. ![]() H, Corresponding periodogram of hourly IEA counts in panel G, showing peak at 24 hours. Black boxes represent nights and white boxes represent days. G, Circadian cycle apparent in hourly IEA over 20 days (shaded area in panel D) along with wavelet-derived circadian periodicity (blue curve) and electrographic seizures. F, Corresponding circular distribution and resultant vectors showing preferential multidien phase of occurrence for electrographic (black) and self-reported (red) seizures. E, Corresponding periodogram of daily IEA counts in panel D, showing peaks at 7, 12, and 32 days. Higher linear density of black dots and crosses in the left half of the timeseries corresponds to increase in the seizure rate in panel A. ![]() D, Multidien cycle over 9 months (shaded area in panel A) apparent in daily interictal epileptiform activity (IEA averaged over calendar days) along with wavelet-derived cycles from 4 to 45 days (blue trace), self-reported seizures (black dots), and electrographic seizures (red crosses). C, Corresponding resultant vector and circannual distribution showing that seizures occur year-round but have slight seasonal preference for spring. B, Corresponding wavelet-periodogram with peak near 365 days underscoring the presence of a circannual cycle. Blue curve is the corresponding inverse wavelet transform between 90 and 450 days. Gradient shows phases as months of the year. ![]() Positive values indicate increased seizure counts over running mean and negative values indicate decreased seizure counts over the running mean. A, Circannual cycle of seizures over 9 years, apparent in detrended seizure rate fluctuations around the running mean. ![]()
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